Thus, CK2 is a regulator of endogenous axis formation in vertebrates. Our results demonstrate that CK2 is required for dorsal axis formation and is for normal upregulation of Wnt signaling genes and targets. Since CK2 phosphorylation of β-catenin stabilizes it, we hypothesized that CK2 might be critical to upregulation of β-catenin in Xenopus embryos and to the process of axis establishment. In Xenopus laevis, dorso-ventral axis formation is dependent upon stabilization of β-catenin in the future dorsal side of the embryo. Personal Development (classes to prepare preteen girls for their teen yrs ages 9-11) MIND YOUR Ps & Qs (an etiquette class for ages 9-11 boys. This pathway has been implicated in diverse aspects of embryonic development, including one of the earliest events in embryonic development, the establishment of the dorso-ventral embryonic axis. In-Depth Personal Development (for the building of self-esteem private/semi-private sessions) MIND YOUR Ps & Qs (an etiquette class for teens male/female) Fresh Faces Session (private teen session on the application of makeup) PRETEENS. One of the substrates of CK2 that is important in embryonic development is β-catenin, the transcriptional co-activator of the canonical Wnt signaling pathway.
A role for CK2α/β in Xenopus early embryonic development A role for CK2α/β in Xenopus early embryonic developmentĭominguez, Isabel Mizuno, Junko Wu, Hao Imbrie, Gregory Symes, Karen Seldin, DavidĬK2 is expressed widely in early embryonic development in several animal models, however its developmental role is unclear.
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